The Sequencing Initiative Suomi (SISu) project is an international collaboration to harmonize and aggregate the whole genome and the whole exome sequence data from Finnish samples and to provide summary data for researchers and clinicians. The SISu website offers a way to search for variants and examine their attributes and appearance in Finnish cohorts. In the current version users can search for summary data on single nucleotide variants and indels from exomes of over 10 000 individuals sequenced in disease-specific and population genetic studies. The first version of the SISu search engine was released in 2014.

Finland's gene pool has been molded by several bottlenecks in Finland's population history and small settler groups inhabitating remote areas in the large country. Therefore a specific reference dataset of sequence variants in Finns is needed, which is why SISu exists. It is an international collaboration between research groups aiming to build tools for genomic medicine. These groups are generating whole genome and whole exome sequence data from Finnish samples. They also provide data resources for the research community. Key groups of the project are from the Universities of Eastern Finland, Oulu and Helsinki; The Institute for Health and Welfare, Finland; Lund University; The Wellcome Trust Sanger Institute; University of Oxford; The Broad Institute of Harvard and MIT; Massachusetts General Hospital; University of Michigan; Washington University in St. Louis, and the University of California, Los Angeles (UCLA). The project is coordinated in the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki.